|
KMID : 0043320080310040419
|
|
Archives of Pharmacal Research
2008 Volume.31 No. 4 p.419 ~ p.423
|
|
|
Synthesis of New Imidazolyl Acetic Acid Derivatives with Anti- inflammatory and Analgesic Activities
|
|
Abdelbaky Nayira A.
Khalifa Maha M.
|
|
|
Abstract
|
|
|
|
We synthesized 2-(4-(4-fluorobenzylidene)-2-(4-fluorophenyl) 5-oxo-4,5-dihydroimidazol-1-yl) acetic acid 3. Chlorination afforded the chloro derivative 4, which reacted with different amines and hydrazine to afford compounds 5-8. Pyrazole, pyrazolone, and thiazolidinone derivatives were also synthesized from Imidazol-1-ylacetic acid hydrazide 8 to give compounds 9-12. Compounds were then evaluated for their anti-inflammatory activity against carrageenaninduced rat paw edema and their analgesic activity using the writhing test in albino mice. Compounds 5, 9, 10, 12 exhibited maximum anti-inflammatory activity, and all the compounds inhibited writhing, with10 and 12 being two times more effective than the reference standard.
|
|
|
KEYWORD
|
|
|
Imidazol-1-yl acetic acid, pyrazole, pyrazolone, thiazolidinone, anti-inflammatory, Analgesic activity
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|
|